8/17/2023 0 Comments Rapid diagnostic test for malariause of rapid diagnostic tests when malaria smears are not rapidly available). In some cases, recommendations are made without a GRADE evaluation because there is significant benefit, with minimal attendant potential harms (e.g. testing for malaria should be done in a febrile traveller returning from an endemic area). Most recommendations in this chapter fall into the category of “good practice”, in the sense that there is no reasonable alternative (e.g. This decision, which was informed by guidance in the CATMAT statement on Evidence based process for developing travel and tropical medicine related guidelines and recommendations Reference 4, was based on several considerations. Recommendations were not developed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. The final chapter was approved by the full CATMAT committee. The working group, with support from the secretariat, was responsible for assessing available literature, synthesis and analysis of the evidence, drafting recommendations, and chapter writing. This chapter was developed by a working group comprised of volunteers from the CATMAT committee. Health care providers should inform travellers of this advice as part of the pre-travel assessment, and physicians should include a travel history in the assessment of febrile patients. Particular attention should be paid to fevers that develop in the three months following travel, the period during which more than 90% of falciparum malaria manifests. For this reason, the Committee to Advise on Tropical Medicine and Travel (CATMAT) recommends that travellers who become ill with an unexplained fever within a year of returning home (regardless of whether malaria prophylaxis was prescribed or taken) should seek immediate medical attention and tell the physician their travel history. falciparum, will present after a longer period, that is, six months or more post-exposure. The large majority of travel-related malaria cases diagnosed in non-endemic countries present within several months of return from an endemic area Reference 3. Hence, clinical assessment, even by experts, cannot reliably confirm or exclude a diagnosis of malaria Reference 2. For example, fever is frequently not cyclic, and splenomegaly is rarely present early in the course of P. Although other signs and symptoms may be present in people with malaria, they are neither sensitive nor specific. It is the most urgent diagnosis to confirm or exclude in the febrile traveller who has been in a malaria-endemic zone. Plasmodium falciparum malaria can be rapidly fatal, particularly in a non-immune host. Manufacturers have sought approval and provided evidence as to the safety and efficacy of their products only when used in accordance with the product monographs or other similarly approved standards or instructions for use. Recommendations for use and other information set out herein may differ from that set out in the product monograph(s) or other similarly approved standards or instructions for use by the licensed manufacturer(s). Persons administering or using drugs, vaccines, or other products should also be aware of the contents of the product monograph(s) or other similarly approved standards or instructions for use. PHAC acknowledges that the advice and recommendations set out in this statement are based upon the best current available scientific knowledge and medical practices, and is disseminating this document for information purposes to both travellers and the medical community caring for travellers. The Committee to Advise on Tropical Medicine and Travel (CATMAT) provides the Public Health Agency of Canada (PHAC) with ongoing and timely medical, scientific, and public health advice relating to tropical infectious disease and health risks associated with international travel. 6.2: Recommendations for malaria diagnostic testing.Table 6.1: Comparison of diagnostic tests for malaria.An Advisory Committee Statement (ACS) from theĬommittee to Advise on Tropical Medicine and Travel (CATMAT)
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